Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-08-15
1998-08-11
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514317, 514330, 514331, 514603, 514604, 514634, 514822, 544398, 544399, 544400, 544402, 546 21, 546229, 546230, 546231, 564237, A61K 31445, C07F 906, C07D24104, C07C27900
Patent
active
057927693
ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sup.1 --R.sup.4, R.sup.7 --R.sup.8, R.sup.a, R.sup.b, R.sup.c, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.
REFERENCES:
patent: 3577432 (1971-05-01), Hesley
patent: 4433152 (1984-02-01), Muramatsu et al.
patent: 5260307 (1993-11-01), Ackermann et al.
patent: 5466811 (1995-11-01), Alexander
Benkert, B. et al., "Relations between structure and the noradrenaline depleting effects of guanidine and amidine derivatives," Chem. Abstr. 83:188217s (1975).
Brzozowski, Z., "Derivatives of 2-mercaptobenzenesulfonamide, I. Synthesis of some S- and N-substituted derivatives of 4-chloro-2-mercapto-5-methylbenzenesulfonamide," Acta. Pol. Pharm 44(6):486-490 (1987).
Jameson, G. W. and D. T. Elmore, "Affinity Chromatography of Bovine Trypsin. A Rapid Separation of Bovine .alpha.-and .beta. Trypsin," Biochem. J. 41:555-565 (1974).
Lespagnol, A. et al., "Investigation of the series of diuretic sulfonamide derivatives," Chem. Abstr. 63:525 (1965).
Miyamoto, S. and M. Kojima, "N.sup.4 -(.omega.-Guanidinoalkanoyl)sulfanilamides," Chem. Abstr. 85:159726t (1976), English abstract of JP 51-75042 (Doc. AM1).
Nippon Chemifar Co., Ltd., "Piperidine Derivatives," Chem. Abst. 101:38355m (1984), English abstract of JP 58-194861 (Doc. AN1).
Protiva, M. et al., "Hypotensive 1-benzyl-4-guanylpiperazines," Chem. Abstr. 82:140187j (1975).
Ryznerski, Z. et al., "Synthesis and Pharmacological Properties of Phenoxylethypiperazine Derivatives," Pol. J. Pharmacol. Pharm. 41:191-199 (1989).
Saulnier, M. G. et al., "An Efficient Method for the Synthesis of Guanidino Prodrugs," Bioorgan. Med. Chem. Letts. 4(16):1985-1990 (Aug. 1994).
Somorin, O. and L. Ameghashitsi, "Synthesis of New Arginine Derivatives as Substrates of Trypsin," Bull. Chem. Soc. Jpn. 59:1593-1595 (1986).
Takahashi, T. and H. Sugimoto, "Quinazoline compounds," Chem. Abstr. 85:46769 (1976), English abstract of JP 50-140474 (Doc. AL1).
Bone Roger F.
Illig Carl R.
Lu Tianbao
Soll Richard M.
Subasinghe Nalin L.
3-Dimensional Pharmaceuticals Inc.
Covington Raymond
Ivy C. Warren
LandOfFree
Guanidino protease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Guanidino protease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Guanidino protease inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-389209