Guanidino derivatives as inhibitors of cell adhesion

Details Guanidino derivatives as inhibitors of cell adhesion Guanidino derivatives as inhibitors of cell adhesion

2007-08-21

2007-08-21

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S256000, C514S263200, C514S265100, C514S269000, C514S300000, C514S303000, C514S263210, C540S553000, C544S276000, C544S277000, C544S280000, C544S331000, C546S113000, C546S118000

Reexamination Certificate

active

10343173

ABSTRACT:
The present invention relates to acylguanidino derivatives of formula (I), in which R1, R2, R3, A, B, X, Y and n have the meanings indicated in claim1, their physiologically tolerable salts and their prodrugs. The compounds of the formula (I) are valuable pharmaceutically active compounds. They are vitronectin receptor antagonists and inhibitors of cell adhesion and bone resorption by osteoclasts. This renders them suitable, for example, for the therapy and prophylaxis of illness which are based on the interaction between vitronectin receptors and their ligands in cell-cell or cell-matrix interaction processes or which can be prevented, alleviated or cured by influencing such interactions. For example, they can be applied for treating and preventing osteoporosis, or for inhibiting undesired angiogenesis or proliferation of cells of the vascular smooth muscles. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as pharmaceutical active ingredients, and pharmaceutical compositions comprising them

REFERENCES:
patent: 0853084 (1998-07-01), None
patent: WO99/32457 (1999-07-01), None
patent: WO 00/31070 (2000-06-01), None
Diane M Biskobing, Expert Opinion on Investigational Drugs, 2003, vol. 12, No. 4, pp. 611-621.

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