Guanidino compounds as regulators of nitric oxide synthase

Details Guanidino compounds as regulators of nitric oxide synthase Guanidino compounds as regulators of nitric oxide synthase

1993-11-30

1995-12-26

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548567, 560 34, 564108, 564104, 564226, 564227, 564229, C07D26302

Patent

active

054789460

ABSTRACT:
Compounds of the formula: ##STR1## useful as regulators of nitric oxide synthase that indirectly modulate cyclic guanosine monophosphate (cGMP), pharmaceutical compositions thereof, for treating disorders of vascular smooth muscles, macrophages, neurons, platelets, bronchial smooth muscles, optic muscles and gastrointestinal smooth muscles, sickle cell anemia and diabetes.

REFERENCES:
patent: 4677226 (1987-06-01), Lutz et al.
patent: 5296498 (1994-03-01), Molen et al.

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