Guanidino compounds as regulators of nitric oxide synthase

Details Guanidino compounds as regulators of nitric oxide synthase Guanidino compounds as regulators of nitric oxide synthase

1993-11-30

1995-01-10

Henley, III, Raymond J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564104, 564226, 564227, 564229, 514634, C07C24900, A01N 3752

Patent

active

053809459

ABSTRACT:
Compounds of the formula: ##STR1## useful as regulators of nitric oxide synthase that indirectly modulate cyclic guanosine monophosphate (cGMP), pharmaceutical compositions thereof, for treating disorders of vascular smooth muscles, macrophages, neurons, platelets, bronchial smooth muscles, optic muscles and gastrointestinal smooth muscles, sickle cell anemia and diabetes.

REFERENCES:
patent: 4677226 (1987-06-01), Lutz et al.
patent: 5296498 (1994-03-01), Molen et al.

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