Guanidinealkyl-1,1-bisphosphonic acid derivatives, process for t

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548414, 548415, A61K 3140, C07F 940

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active

056611749

ABSTRACT:
Compounds of the tautomeric formula Ia, Ib or Ic, ##STR1## where R is a radical of the formula ##STR2## are effective compounds for the treatment and prophylaxis of degenerative bone disorders. They are used as pharmaceuticals.

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"New Methods of Preparative Organic Chemistry IV, Synthesis Using Heterocyclic Amides (Azolides)", Staab, H.A., Angew. Chem. Internat. Edit. 1(7):351-367 (1962).
Advanced Organic Chemistry--Reactions, Mechanisms, and Structure March J., Fourth Edition, pp. 348-352. (1992).
"Zur Guanylierung von Aminen mit O-Methyl-Isoharnstoff-Sulfat", Weiss et al., Chemiker-Zeitung, 98(12):617-621 (1974).

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