Guanidine derivatives useful in therapy as inhibitors of nitric

Details Guanidine derivatives useful in therapy as inhibitors of nitric Guanidine derivatives useful in therapy as inhibitors of nitric

1998-11-16

1999-12-07

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514217, 5142355, 5142372, 514316, 514327, 514408, 514422, 540588, 540589, 544129, 544141, 546186, 546189, 546231, 548523, 548565, 548566, 548569, 548950, A61K 31445, C07D295215, C07D21706, C07D22322, C07D20504

Patent

active

05998399&

ABSTRACT:
Method of treating or reducing the risk of human disease or condition in which the synthesis or oversynthesis of nitric oxide forms a contributory part wherein a therapeutically effective amount of the compound of formula (I) as defined in the specification is administered to a person suffering from or susceptible to such disease or condition.

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patent: 5268373 (1993-12-01), Breslin et al.
Jonczyk et al, "Reactions of Organic Anions . . . ," Communications, pp. 882-883 (1978).
Forstermann et al, "Induced RAW 264.7 macrophages express soluble . . . ," European Journal of Pharmacology, vol. 225, pp. 161-165 (1992).
Bredt et al, "Isolation of nitric oxide synthetase . . . ," Proc. Natl. Acad. Sci. USA, vol. 87, pp. 682-685 (1990).
Pollock et al, "Purification and characterization of particulate . . . ," Proc. Natl. Acad. Sci. USA, vol. 88, pp. 10480-10484 (1991).

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