Guanidine derivatives of imidazoles and thiazoles

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424273R, 2603068R, 260326S, 260326N, 548337, C07D27738, C07D23388, A61K 31425, A61K 31415

Patent

active

041653785

ABSTRACT:
The invention relates to guanidine derivatives of imidazoles and thiazoles which are histamine H-2 antagonists and which inhibit the secretion of gastric acid, to methods for their manufacture, to pharmaceutical compositions containing them and to methods of using such guanidine derivatives and compositions. The guanidine derivatives are of the general formula I: ##STR1## in which X is S or NH, Y is O, S, or SO, m is 1 to 4 and n is suitably 1 to 4, R.sup.1 is hydrogen, halogen or alkyl, R.sup.2 is hydrogen, alkyl, alkanoyl or aroyl, A is a 3,4-dioxocyclobuten-1,2-diyl radical or C=Z in which Z is O, S, NCN, NNO.sub.2, CHNO.sub.2, NCONH.sub.2, C(CN).sub.2, NCOR.sup.3, NCO.sub.2 R.sup.3, NSO.sub.2 R.sup.3 or NR.sup.4 in which R.sup.3 is alkyl or aryl and R.sup.4 is hydrogen or alkyl, B is alkoxy or alkylthio or NR.sup.5 R.sup.6 in which R.sup.5 and R.sup.6 are independently hydrogen, alkyl, alkenyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, alkylaminoalkyl or dialkylaminoalkyl; and the salts thereof.

REFERENCES:
patent: 3876647 (1975-04-01), Durant et al.
patent: 3897444 (1975-07-01), Durant et al.
patent: 3905984 (1975-09-01), Durant et al.
patent: 3920822 (1975-11-01), Durant et al.
patent: 3932427 (1976-01-01), Durant et al.
patent: 3950333 (1976-04-01), Durant et al.
patent: 3950353 (1976-04-01), Durant et al.
patent: 3975530 (1976-08-01), Durant et al.
patent: 4018391 (1977-04-01), Durant et al.
patent: 4018928 (1977-04-01), Durant et al.
patent: 4018931 (1977-04-01), Durant
patent: 4022797 (1977-05-01), Durant et al.
patent: 4038408 (1977-07-01), Durant et al.
patent: 4049672 (1977-09-01), Durant et al.
patent: 4053473 (1977-10-01), Durant et al.
patent: 4062863 (1977-12-01), Ganellin et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Guanidine derivatives of imidazoles and thiazoles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Guanidine derivatives of imidazoles and thiazoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Guanidine derivatives of imidazoles and thiazoles will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1323788

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.