Guanidine derivatives compositions and use

Details Guanidine derivatives compositions and use Guanidine derivatives compositions and use

1991-06-24

1993-11-09

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142372, 514319, 514321, 514326, 544130, 546190, 546198, 546201, 546205, 546231, A61K 31445, A61K 31535, C07D40112, C07D41312

Patent

active

052603075

ABSTRACT:
Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.

REFERENCES:
patent: 4227006 (1980-10-01), Okamoto et al.
patent: 4258192 (1981-03-01), Okamoto et al.
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 5037808 (1991-08-01), Tjoeng et al.
patent: 5053393 (1991-10-01), Tjoeng et al.
J. Med. Chem. 23, 1980, 1293-9.
Pharmazie 39, 1984, 226-230.

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