Guanidine derivatives and their medical use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C540S553000

Reexamination Certificate

active

08048877

ABSTRACT:
This invention relates to novel guanidine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

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patent: 869181 (1961-05-01), None
patent: WO-95/20950 (1995-08-01), None
Jantzen and Robinson. Modern Pharmaceutics, 1996, p. 596.
Sailer et al., Mol. Cell. Neurosci. 2004 26 pp. 458-469.
Liegeois J-F et al., Current Medicinal Chemistry 2003, 10, pp. 625-647.
Struve et al., J. Org. Chem. 1977 42 (25) p. 4035-4040.

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