Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-11-22
1996-07-02
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514211, 514212, 514221, 5142372, 514314, 540315, 540316, 540320, 540326, 540331, 540481, 540544, 540569, 544130, 546172, 546189, 546202, 546212, 546231, 546233, 546235, 546246, A61K 31445, C07D21122, C07D21126
Patent
active
055322328
ABSTRACT:
Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
REFERENCES:
patent: 4433152 (1984-02-01), Muramatsu
patent: 5254569 (1993-10-01), Cheeseman
patent: 5405854 (1995-04-01), Ackermann
Ackermann Jean
Banner David
Gubernator Klaus
Hadvary Paul
Hilpert Kurt
Datlow Philip I.
Epstein William H.
Gould George M.
Hoffmann-La Roche Inc.
Pokras Bruce A.
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