Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-08-04
1996-12-10
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514212, 5142315, 5142382, 540481, 540598, 544111, 544162, 544168, 544159, A61K 31535, C07D26530, C07D41312
Patent
active
055831338
ABSTRACT:
Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
REFERENCES:
patent: 4227006 (1980-10-01), Okamoto et al.
patent: 4258192 (1981-03-01), Okamoto et al.
patent: 4433152 (1984-02-01), Muramatsu
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 5037808 (1991-08-01), Tjoeng et al.
patent: 5053393 (1991-10-01), Tjoeng et al.
patent: 5254569 (1993-10-01), Cheeseman
patent: 5405854 (1995-04-01), Ackermann et al.
J. Med. Chem. 23, 1980, 1293-9, Kikumoto et al.
Pharmazie 39, 1984, 226-230, Wagner et al.
Ackermann Jean
Banner David
Gubernator Klaus
Hadvary Paul
Hilpert Kurt
Datlow Philip I.
Epstein William H.
Hoffmann-La Roche Inc.
Johnston George W.
Pokras Bruce A.
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