Guanidine compounds useful as histamine H2-antagonists

Details Guanidine compounds useful as histamine H2-antagonists Guanidine compounds useful as histamine H2-antagonists

1985-02-12

1987-09-29

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514237, 514238, 514256, 514318, 514326, 514332, 514335, 514340, 514341, 514342, 514343, 546192, 546208, 546193, 548128, 548130, 548132, 548133, 548184, 548194, 548232, 548236, 548255, 548265, 548266, 548337, 548377, A01K 3141, C07D24904, C07D40112

Patent

active

046969330

ABSTRACT:
The invention relates to amide derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the formula I: ##STR1## in which R.sup.1 is a hydrogen or 1-10C alkyl, 3-8C cycloalkyl, 4-14C cycloalkyl, 3-6C alkenyl, 3-6C alkynyl, 1-6C alkanoyl, 6-10C aryl, 7-11C aralkyl or 7-11C aroyl, the aryl, aralkyl and aroyl radical being optionally substituted; ring X is a heterocyclic ring as defined in the specification; A is phenylene or 5-7C cycloalkylene, or a 1-8C alkylene into which is optionally inserted one or two groups; D is O or S; and R.sup.2 and R.sup.3 are hydrogen or a variety of radicals described in the specification: and the pharmaceutically-acceptable acid-addition salts thereof. Manufacturing processes and pharmaceutical compositions are also described.

REFERENCES:
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patent: 4451463 (1984-05-01), Laye
patent: 4496571 (1985-01-01), Yellin et al.
patent: 4570000 (1986-02-01), Jones et al.
Laye, Chem. Abst., 98-143463n.
Yellin et al, Chem. Abst., 98-89389c.
Hales et al, Chem. Abst., 101-110910h.
Imperial Chemical Industries PLC, Chem. Abst., 101-110911j.
Kirkland et al, Chem. Abst., 104-19576e.
Yamanouchi Pharmaceutical Co. Ltd., Chem. Abst., 96-68976k, eq. JP.81108777.
Hirata et al, Chemical Abstract, 94-13979w, eq. Ger. Offen. 3008056.

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