Guanidine compounds as anesthetics and for treatment of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

07868028

ABSTRACT:
Novel guanidine compounds having the formulain which R1, R2and R4are as defined, are effective as sodium channel blockers in neuronal mammalian cells and as anesthetics and/or analgesics, particularly local spinal and/or epidural anesthetics, for alleviation of neuropathic pain, for providing a neuroprotective effect, and for producing anti-convulsant effects.

REFERENCES:
patent: 5688830 (1997-11-01), Berger et al.
patent: 1177792 (2002-02-01), None
patent: 2002155060 (2002-05-01), None
patent: 1326608 (1987-07-01), None
Popov et al., Khimlya Geterotslklichesklkh Soedinenii (1996), (10), 1352-1357, CAPLUS Accession No. 126:47152.
Anisimova et al., Khimiko-Farmatsevticheskii Zhurnal (1987), 21(3), 313-319, CAPLUS Accession No. 1988:5879.
Anisimova et al., Khimiya-Gaterotsiklicheskikh Soedinenii (1986), (7), 918-925, CAPLUS Accession No. 1987:477696.

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