Guaiazulene derivatives and their methods of use

Details Guaiazulene derivatives and their methods of use Guaiazulene derivatives and their methods of use

1986-06-26

1988-07-05

Lee, Mary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549458, A61K 3134, C07D30793

Patent

active

047555297

ABSTRACT:
This invention relates to novel guaiazulene compositions which are useful as antitumor, immunomodulatory and antifungal compositions and a process of producing guaiazulene compositions and a method for immunomodulation and inhibiting tumors and fungi utilizing guaiazulene compositions. More particularly, the compositions are derived from marine gorgorian Acalycigorgia, sp.

REFERENCES:
Takeda et al, Chem. Pharm. Bull., 1, pp. 164-169, (1953).
Fusetani et al, Experientia, 37, pp. 680-681, (1981).
Li et al, Tet. Letters, 25 (42), pp. 4707-4708, (1984).
Imre et al, Experientia, 37, pp. 442-443, (1981).
Li et al, Tet. Letters, 25 (6), pp. 587-590, (1984).
Takeda et al, J. Chem. Suc., pp. 2591-2597, (1964).
Chem. Abstracts, vol. 67, 54032p, (1967)--Abstract of Shionogi, Japanese Pat. No. 5537, 3-7-1967.
Li et al, Tet. Letters, v. 25 (20), pp. 2109-2110, (1984).

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