Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-04-22
1998-12-08
Carlson, Karen
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435325, 4353201, 536 235, 530350, C12P 2106, C12N 1500, C07H 1700, C07K 14435
Patent
active
058467750
ABSTRACT:
The present invention provides a human GTPCH regulatory protein (HGCR) and polynucleotide which encode HGCR. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HGCR.
REFERENCES:
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Niederwieser, A., et al., "GTP cyclohydrolase I deficiency, a new enzyme defect causing hyperphenylalaninemia with neopterin, biopterin, dopamine, and serotonin deficiencies and muscular hypotonia", Eur J Pediatr, 141: 208-214 (1984).
Ichinose, H., et al., "Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene", Nature Genetics, 8: 236-242 (1994).
Harada, T., et al., "Feedback Regulation Mechanisms for the Control of GTP Cyclohydrolase I Activity", Science, 260: 1507-1510 (1993).
Barnett, M.J., et al., (GI 152439) GenBank Sequence Database (Accession M33495), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (1990).
Barnett, M.J., et al., (GI 152440) GenBank Sequence Database (Accession M33495), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (1990).
Milstien, S., et al., (GI 1698997) GenBank Sequence Database (Accession U78190), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (Nov. 4, 1996).
Milstien, S., et al., (GI 1698996) GenBank Sequence Database (Accession U78190), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (Nov. 4, 1996).
Hillman Jennifer L.
Shah Purvi
Billings Lucy J.
Carlson Karen
Incyte Pharmaceuticals Inc.
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