Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2006-11-14
2006-11-14
Ramirez, Delia M. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S015000, C435S320100, C435S069100, C435S252300, C435S325000, C536S023100, C536S023200, C536S023500, C530S350000
Reexamination Certificate
active
07135321
ABSTRACT:
The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
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Calderon-Cacia Maria
Coit Doris G
Fang Eric Y
Hall John A
Harrison Stephen D
Chiron Corporation
Harbin Alisa A.
Potter Jane E. R.
Ramirez Delia M.
Suh Young J.
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