GSK-3β expressed in a transgenic mouse

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal

Reexamination Certificate

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C800S003000, C800S009000, C800S012000, C800S025000

Reexamination Certificate

active

10276460

ABSTRACT:
A transgenic animal in which GSK-3β protein is over-expressed is useful as a model for neurodegenerative disease.

REFERENCES:
patent: WO95/05466 (1995-02-01), None
patent: WO98/03644 (1998-01-01), None
patent: WO 01/02552 (2001-01-01), None
Ristevsk, S. Making Better Transgenic Models. Molecular Biotechnology. 2005, vol. 29, pp. 153-163.i.
Montoliu, L. Gene Transfer Strategies in Animal Transgenesis. Cloning and Stem Cells. 2002, vol. 4, No. 1, pp. 39-46.
Echeverria et al. Rat Transgenic Models with a Phenotype of Intracellular A-Beta Accumulation in Hippocampus and Cortex. J. Alzheimer's Dis. 2004, vol. 6, pp. 209-219.
Gingrich and Roder, “Inducible Gene Expression in the Nervous System of Transgenic Mice”Annu. Rev. Neurosci. 21:377-405, 1998.
Nagai et al., “Rats Expressing Human Cytosolic Copper-Zinc Superoxide Dismutase Transgenes with Amyotrophic Lateral Sclerosis: Associated Mutations Develop Motor Neuron Disease”J. Neurosci. 21:9246-9254, 2001.
Si-Hoe et al., “Production of Transgenic Rodents by the Microinjection of Cloned DNA into Fertilized One-cell Eggs”Mol. Biotechno. 17:151-82, 2001 (Abstract only).
Ripps et al., “Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis”Proc. Natl Acad Sci USA 92:689-693, 1995.
Gordon et al., “Genetic transformation of mouse embryos by microinjection of purified DNA”Proc Natl Acad SciUSA 77:7380-7384, 1980.
Brownlees et al. (1997) “Tau Phosphorylation in Transgenic Mice Expressing Glycogen Syntheses Kinase—3Beta Transgenes,” Neuro report, Rapid Communications of Oxford 8(15):3251-3255.
Mayford et al. (1996) “Control of Memory Formation Through Regulated Expression of a CAMKII transgene” Science 274:1678-1683.
Lucas et al. (2001) “Decreased Nuclear B-Catenin, Tau Hyperphosphorylation and Neurodigeneration in GSK-3B Conditional Transgenic Mice” EMBO J. 20(1/2):27-39.
Baron et al. (1995) “Co-Regulation of Two-Gene Activities by Tetracycline via a bidirectional promoter”, Nucleic Acid Res. 23(17):3605-3606.
Ishiguro et al. (1993) “Glycogen synthesis kinase 3 Beta is identical to tau protein kinase I generating several epitopes of paired helical filaments” FEBS 6 letters 325(3):167-172.

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