Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Derived from musculoskeletal system – other than cardiac muscle
Patent
1988-08-12
1992-10-13
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Derived from musculoskeletal system, other than cardiac muscle
530840, A61K 3532
Patent
active
051549310
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to a therapeutic composition for use in parodontal treatment.
According to the findings of the WHO, inflammatory diseases of the teeth-holding system (parodontitis, often also called "parodontosis") are amongst the most widely distributed chronic diseases The long-term preservation of teeth is endangered by the disintegration of the jaw bone occurring in these diseases (especially in the form of deep bone cavities).
Although the previously propagandized rather radical methods involving recontouring of the bone and the soft tissue provided a result that could readily be checked, at the same time parodontal regeneration was not attempted and occasionally even the loss of healthy parodontal tissue was caused;
2. Brief Description of the Prior Art
The aim of modern parodontal treatment is the regeneration of parodontal tissue by cleaning the roots of teeth to remove microbial plaque (concrements), and to remove from the bone cavities tissue modified by inflammation. Numerous methods of treatment of parodontal lesions have been developed for this; cf., inter alia, Prichard 1975, Rosling et al. 1976, Polson et al. 1978, Ramfjord & Ash 1979 and Rateitschak et al. 1984. A certain parodontal regeneration should occur either by merely cleaning the osseous lesions, or by implanting various materials into the bone cavities; The implantation material preferably used today is hydroxyapatite which, according to clinical tests, appears to bring about a greater repair of the lesion than simple root and lesion cleaning;
In all of the cases mentioned, however, there is one fundamental problem. Daughter cells growing out from the oral epithelium form along the surface of the root a new epithelium, which in most cases covers the whole of the treated surface of the root and later may even lie at the apex of the regenerated bone. This epithelium may promote a new inflammation in the depths of the treated bone lesion. The basic problem, however, is that the deep growth of the epithelium proceeds more quickly than does the osseous and desmodontal regeneration.
In order to prevent this deep growth of the epithelium, according to more recent research the bone lesion was covered, for example, with millipore filter before the mucoperiosteal flap was put back in position. This is intended to render possible parodontal regeneration without interference from deep growth of the epithelium. This process appears very complicated, however, and the prognosis is uncertain as a result of a high quota of possible errors.
SUMMARY OF THE INVENTION
One aim of the invention is to provide a therapeutic composition with which the regeneration time is reduced and the risk of deep growth of the epithelium is prevented.
This object is achieved in accordance with the invention by a therapeutic composition having a growth-stimulating material and a solid carrier.
The person skilled in the art is familiar with growth-stimulating materials; attention is drawn to the prior art, which is referred to in the following in connection with a growth-stimulating material according to the invention that is especially suitable.
Growth-stimulating materials are available in liquid or paste form, their growth-stimulating action being attributable to proteins. The purpose of the carrier provided in accordance with the invention is to bind the growth-stimulating material so as to prevent it from being washed away from the site of application.
Examples of carriers that can be used in accordance with the invention are partially to fully absorbable carriers, especially hydroxyapatite (HAP), tricalcium phosphate, collagen and plastics. As a result of the absorbability of the carrier, the therapeutic composition according to the invention can disappear at the site of application, whilst the bone is built up again by the action of the growth-stimulating material.
Growth-promoting activities of bone material have been described by various research groups; see Simpson E. (1984) TIBS 9, pp. 527-530 and
REFERENCES:
patent: 4434094 (1984-02-01), Seyedin et al.
patent: 4627982 (1986-12-01), Seyedin et al.
patent: 4804744 (1989-02-01), Sen
Urist et al. BA78:730 1984.
Delling Gunter
Kruger Wolfgang
Kukoschke Karl G.
Mayer Hubert
Schluter Klaus D.
Gesellschaft fur Biotechnologische Forschung mbH (GBF)
Robinson Douglas W.
Witz Jean C.
LandOfFree
Growth-stimulating material derived from porcine bone therefor a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Growth-stimulating material derived from porcine bone therefor a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Growth-stimulating material derived from porcine bone therefor a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1299118