Growth regulation and related applications of opioid antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514812, A61K 3141

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active

046893326

ABSTRACT:
A method for regulating the growth processes in a myriad of cells, tissues, organ systems and unicellular and multicellular organisms including plants, animals and man by the administration of effective amounts of the opioid antagonists naloxone, naltrexone, their analogs metabolites derivatives, and/or mixtures thereof. At the cellular level, the growth processes entail all mitotic events and related processes including cell proliferation, as well as cell migration and cell differentiation, and at the somatic or organismal level, anatomical, behavioral and neurological development, metamorphisis and maturation. Growth regulation can be effected in vivo and/or in vitro.

REFERENCES:
Chem Abst., 88:183495z; Chihara et al., 1978.
Chem Abst., 93:37699f, Grandison et al., 1980.
Chem Abst., 100:18090x, Zagon et al., 1984.
Chem Abst., 103:207085x, Ilinskii et al., 1985.
"Naltrexone Modulates Growth in Infant Rats", Ian S. Zagon and Patricia J. McLaughlin, Life Sciences, vol. 33, pp. 2449-2545, 1983 Pergamon Press Ltd.

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