Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Culture medium – per se
Patent
1998-03-18
2000-07-11
Reeves, Julie
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Culture medium, per se
435404, 435406, 435408, 435384, 435387, 435391, 435392, C12N 506, C12N 508
Patent
active
060871741
ABSTRACT:
The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a cytokine relative to the unmodified tumor cell line, and (c) administering the tumor cell line to a mammalian host having at least one tumor that is the same type of tumor as that from which the tumor cell line was obtained, wherein the tumor cell line is allogeneic and is not MHC-matched to the host. The present invention also provides a pancreatic tumor cell line, a method and medium for obtaining such a tumor cell line, and a composition comprised of cells of a purified pancreatic tumor cell line.
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Jaffee Elizabeth M.
Levitsky Hyam I.
Pardoll Drew M.
Johns Hopkins University School of Medicine
Reeves Julie
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