Growth-inhibitory factor obtained from human brain

Details Growth-inhibitory factor obtained from human brain Growth-inhibitory factor obtained from human brain

1991-05-06

1993-05-25

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 21, 530324, 530399, 530326, 930120, 930DIG820, A61K 9702, C07K 700

Patent

active

052140318

ABSTRACT:
Disclosed are a growth-inhibitory factor which is a pure protein extracted from human brain and having inhibitory action against neurotrophic activity and a cDNA coding for a protein existing in human brain and the lysate from E. coli transfected with the cDNA having growth-inhibitory action, and also a method of inducing growth-inhibiting activity for treatment of Alzheimer disease by using the protein.

REFERENCES:
Uchida et al., Neuron, 7, 337-347, Aug. 1991.
Uchida et al., Chem. Absts., 115 (23):253245w, 1991.

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