Growth inhibitory factor from urogenital sinus

Details Growth inhibitory factor from urogenital sinus Growth inhibitory factor from urogenital sinus

1992-08-11

1996-03-05

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530324, A61K 3800, C07K 200, C12P 2100, G01N 3353

Patent

active

054968003

ABSTRACT:
A process is provided for purifying Urogenital Sinus Derived Growth Inhibitory Factor (UGIF) from embryonic tissue which comprises chromatographing medium from cultures or culture-derived spheroids of embryonic tissue derived from the urogenital sinus by gel filtration chromatography. Further purification by reverse phase high pressure liquid chromatography is also demonstrated. The UGIF is obtained in 70-fold to 8000-fold purification over the conditioned medium. A UGIF composition of matter is also provided, as is a method for treating neoplasia with UGIF.

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