Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2000-01-20
2001-08-21
Wang, Andrew (Department: 1643)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C435S006120, C435S325000, C435S366000, C435S375000, C536S024500
Reexamination Certificate
active
06277832
ABSTRACT:
TECHNICAL FIELD
The present invention relates to a growth inhibitor for leukemia cells comprising an antisense nucleotide derivative.
BACKGROUND ART
Wilms' tumor is a pediatric kidney tumor that occurs as a result of deactivation of both allele of the Wilms' tumor gene (WT1) located on chromosome 11p13 (Call, K. M., et al., Cell 60: 509, 1990). A non-coding upstream sequence of WT1 (C. E. Campbell, et al., Oncogene 9: 583-595, 1994) and a coding region that includes the intron (D. A. Haber, et al., Proc. Natl. Acad. Sci. USA, 88: 9618-9622, 1991) have previously been reported, and they are expected to be involved in the growth and differentiation of the tumor and so forth (D. A. Haber, et al., Proc. Natl. Acad. Sci. USA, 88: 9618-9622, 1991).
However, it was not known that WT1 is involved in the growth of leukemia cells, and that an antisense oligonucleotide derivative to WT1 suppresses and inhibits growth of leukemia cells.
DISCLOSURE OF THE INVENTION
Thus, the present invention provides a growth inhibitor for leukemia cells comprising an antisense nucleotide derivative to Wilms' tumor gene (WT1).
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Inoue Kazushi
Sugiyama Haruo
Yamagami Tamotsu
Foley & Lardner
Tadamitsu Kishimoto
Wang Andrew
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