Growth hormone secretagogues

Details Growth hormone secretagogues Growth hormone secretagogues

2007-11-20

2007-11-20

Weber, Jon (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C548S495000

Reexamination Certificate

active

10837620

ABSTRACT:
The invention relates to compounds of formula Iwhich are useful for elevating the plasma level of growth hormone in a mammal as well as for the treatment of growth hormone secretion deficiency, growth retardation in child and metabolic disorders associated with growth hormone secretion deficiency.

REFERENCES:
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patent: 5912234 (1999-06-01), Ruoslahti et al.
patent: 6025471 (2000-02-01), Deghenghi et al.
patent: WO95/14666 (1995-06-01), None
patent: WO96/15148 (1996-05-01), None
Bowers, C., “Zenobiotic Growth Hormone Secretagogues: Growth Hormone Releasing Peptides”, Eds. B. Bercu and R.F. Walker, Springer-Verlag, pp. 9-28, New York (1996).
Deghenghi R. et al., “Small Peptides as Potent Releasers of Growth Hormone”,J. Ped. End. Metab.,vol. 8, pp. 311-313 (1996).
Deghenghi, R., “Growth Hormone Releasing Peptides”, pp. 85-102 (1996).
Deghenghi, R., “The development of‘impervious peptides’ as growth hormone secretagogues”,Acta Paediatr Suppl, vol. 423, pp. 85-87 (1997).
Deghenghi, R., et al., “Impervious peptides as growth hormone secretagogues,” Pept. Sci.: Present, Future, Proc. Int. Pept. Symp., pp. 411-412, 1999 (Abstract).
Ghigo, E. et al., “Growth hormone-releasing peptides”,European Journal of Endocrinology, vol. 136, pp. 445-460 (1997).
Kojima, M. et al., “Ghrelin is a growth-hormone-releasing acylated peptide from stomach”,Nature, vol. 402, pp. 656-660 (1999).
McDowell, R.S., et al., “Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation,”Proc Nat'l Acad Sci USA, vol. 92, No. 24, pp. 11165-11169 (1995) (Abstract).
Muccioli, G., et al. “Tissue Distribution of GHRP Receptors in Humans,” Abstracts IV European Congress of Endocrinology, Sevilla, Spain, 1998.
Muccioli, M. et al., “Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland”,Journal of Endocrinology, vol. 157, pp. 99-106 (1998).
Paris, M., et al., “Synthesis of Peptide Aldehydes on Solid Support using Ozonolysis,”Tetrahedron Letters, vol. 39, pp. 7287-7290 (1998).
Patchett, A.A. et al., “Design and biological activities of L-163,191 (MK-0677): A potent, orally active growth hormone secretagogue,”Proc Nat'l Acad Sci USA, vol. 92, No. 15, pp. 7001-7005, 1995.
Veeraragavan, K. et al., “Growth Hormone-Releasing Peptide (GHRP) Binding to Porcine Anterior Pituitary and Hypothalamic Membranes”,Life Sciences, vol. 50, pp. 1149-1155 (1992).

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