Growth hormone secretagogues

Details Growth hormone secretagogues Growth hormone secretagogues

2005-03-01

2005-03-01

Meller, Michael (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

06861409

ABSTRACT:
The invention relates to compounds of formula Iwhich are useful for elevating the plasma level of growth hormone in a mammal as well for the treatment of growth hormone secretion deficiency, growth retardation in child and metabolic disorders associated with growth hormone secretion deficiency.

REFERENCES:
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patent: WO 9615148 (1996-05-01), None
Paris et al., Tetrahedron Letters, 39, 7287-90, 1998.*
McDowell, R.S., et al., “Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation,” Proc. Nat'l Acad. Sci. USA, 92 (24): 11165-11169 (1995). (Abstract).
Patchett et al., A.A., “Design and biological activities of L-163,191 (MK-0677): A potent, orally active growth hormone secretagogue,” Proc. Nat'l. Acad. Sci. USA, 92 (15): 7001-7005, Jul. 1995.
Muccioli, G., et al. “Tissue Distribution of GHRP Receptors in Humans,” Abstracts IV European Congress of Endocrinology, Sevilla, Spain, 1998.
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C. Bowers, “Zenobiotic Growth Hormone Secretagogues: Growth Hormone Releasing Peptides”, Eds. B. Bercu and R.F. Walker, Springer-Verlag, pp. 9-28, New York (1996).
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R. Deghenghi et al., “Small Peptides as Potent Releasers of Growth Hormone”,J. Ped. End. Metab., 8, pp. 311-313 (1996).
R. Deghenghi, “The development of ‘impervious peptides’ as growth hormone secretagogues”,Acta Paediatr Suppl, 423, pp. 85-87 (1997).
E. Ghigo et al., “Growth hormone-releasing peptides”,European Journal of Endocrinology, 136, pp. 445-460 (1997).
M. Kojima et al., “Ghrelin is a growth-hormone-releasing acylated peptide from stomach”,Nature, 402, pp. 656-660 (1999).
M. Muccioli et al., “Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland”,Journal of Endocrinology, 157, pp. 99-106 (1998).
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