Growth hormone-releasing peptides and method of treating animals

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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530324, 530350, 530399, A61K 3736, C07K 700

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active

054160731

ABSTRACT:
The present invention relates to novel growth hormone-releasing peptides and method for increasing the release of growth hormone levels in mammals, as well as method for increasing milk production in dairy cows and increasing growth rates of animals, such as cattle, sheep, swine, and others. The novel peptides of this invention surprisingly are effective for releasing growth hormone levels in animals by replacing the natural amino acids in positions 1, 2, 3, 8, 9, 10, 12, 21 and 27, as well as derivatizing the N-terminal amino acid residue in human pancreatic islet tumor origin growth hormone-releasing factor.

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Merrifield, J. Am. Chem. Soc., vol. 85, 2149-2154, 1963.
Grossman et al., "Response to Analogues of Growth Hormone-Releasing Hormone in Normal Subjects, and in Growth-Hormone Deficient Children and Young Adults", Clinical Endocrinology; 21, 321-324 (1984).

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