Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence
Reexamination Certificate
2003-08-08
2008-11-25
Kosar, Andrew D. (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
4 to 5 amino acid residues in defined sequence
C514S017400, C424S001690
Reexamination Certificate
active
07456253
ABSTRACT:
Disclosed are peptide and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, that are useful as GHRP analogs: R1-A2-A3-A4-A5-R2(I) or a pharmaceutically acceptable salt thereof, wherein: A1is Aib, Apc or Inp; A2is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A3is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A4is 2Fua, Om, 2Pal, 3Pal, 4Pal, Pff, Phe, Pim, Taz, 2Thi, 3Thi, Thr(Bzl); A5is Apc, Dab, Dap, Lys, Orn, or deleted; R1is hydrogen, (C1-6)alkyl, (C5-14)aryl, (C1-6)alkyl(C5-14)aryl, (C3-8)cycloakyl, or (C2-10)acyl; and R2is OH or NH2; and pharmaceutical compositions and methods of use thereof.
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GHS are reliable provocative tests for the diagnosis of GH deficiency but, as orally active growth-promoting agents, they are not comparable with human recombinant GH in terms of efficacy (abstract).
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Audet Maury
Feeney Alan F.
Kosar Andrew D.
Societe de Conseils de Recherches et d'Applications Scientifique
Uhm Tony K.
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