Growth hormone-releasing factor analogs

Details Growth hormone-releasing factor analogs Growth hormone-releasing factor analogs

1989-09-18

1992-08-11

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530342, 530399, 424422, 604 93, C07K 710, A61K 3702

Patent

active

051378728

ABSTRACT:
Human Growth Hormone-Releasing Factor (hGRF) analogs having the sequence [Pro.sup.0, X.sup.15, Y.sup.27 ]-hGRF(1-A)-B, wherein X is selected from the group consisting of Ala and Gly, Y is selected from the group consisting of Ile, Leu, Val, Nle and Met, A has a value from 29-44, and B is NH.sub.2, OH or COOH are synthesized and administered to animals to stimulate the release of Growth Hormone (GH).

REFERENCES:
patent: 4659693 (1987-04-01), Nestor
patent: 4728726 (1988-03-01), Rivier et al.
patent: 4801456 (1989-01-01), Drengler
patent: 4833166 (1989-05-01), Grosvenor et al.
patent: 4839344 (1989-06-01), Bowers et al.
Frohman et al., Rapid Enzymatic Degradation of Growth Hormone-releasing Hormone by Plasma In Vitro and In Vivo to a Biologically Inactive Product Cleaved at the NH.sub.2 Terminus, J. Clin. Invest., vol. 78, pp. 906-913 (1986),
Hodate et al., Response of Growth Hormone Release to Human Growth Hormone-Releasing Factor and Its Analogs in the Bovine, Endocrinol. Japan, 33 (4) pp. 519-525 (1986).
Karashima et al., Effect of Long-Term Administration of an Analog of Growth Hormone-Releasing Factor on the GH Response in Rats, Life Sciences, vol. 40, pp. 2437-2444 (1987).

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