Growth hormone release factor analogs

Details Growth hormone release factor analogs Growth hormone release factor analogs

1983-09-21

1986-10-14

Moyer, Donald B.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C07K 710

Patent

active

046171495

ABSTRACT:
A class of compounds having growth hormone releasing activity is described. These compounds have the formula H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser- Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-X-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-A rg-Gly-Ala-Arg-Ala-Arg-Leu-Y in which Y is OH or NH.sub.2 and X is selected from the group consisting of Met(O), Met(S-Me), Hse, Gln, Asn, Ser, Thr, Leu, Ile, Ala, Gly, Pro, Val, Phe, Trp, Tyr, Cys, Lys, Arg, His, Glu, and Asp.

REFERENCES:
patent: 4529595 (1985-07-01), Rivier et al.
Rivier et al., 8th American Peptides Symposium, Tucson, Arizona, 237 (1983), May 22-27.
R. Guillemin et al., Growth Hormone-Releasing Factor from a Human Pancreatic Tumor that Caused Acromegaly, Science, 218:585-587, 1982.
F. S. Esch et al., Characterization of a 40 Residue Peptide from a Human Pancreatic Tumor with Growth Hormone Releasing Activity, Biochem. Biophys. Res. Comm., 109:152-158, 1982.
J. Rivier et al., Characterization of a Growth Hormone-Releasing Factor from a Human Pancreatic Islet Tumour, Nature, 300:276-278, 1982.
W. B. Wehrenberg et al., Somatocrinin, Growth Hormone Releasing Factor, Stimulates Secretion of Growth Hormone in Anesthetized Rats, Biochem. Biophys. Res. Comm,. 109:382-387, 1982.
P. Brazeau et al., Somatocrinin (Growth Hormone Releasing Factor) In Vitro Bioactivity; Ca.sup.++ Involvement, cAMP Mediated Action and Additivity of Effect with PGE.sub.2, Biochem. Biophys. Res. Comm., 109:588-594, 1982.
J. Spiess et al., Sequence Analysis of a Growth Hormone Releasing Factor from a Human Pancreatic Islet Tumor, Biochemistry, 21:6037-6040, 1982.
M. O. Thorner et al., Human Pancreatic Growth-Hormone-Releasing Factor Selectively Stimulates Growth-Hormone Secretion in Man, Lancet, Jan. 1/8, pp. 24-28, 1983.
F. S. Esch et al., Primary Structures of Three Human Pancreas Peptides with Growth Hormone-Releasing Activity, J. Biol. Chem., 258:1806-1810, 1983.
A. Arimura et al., In Vitro Pituitary Hormone Releasing Activity of 40 Residue Human Pancreatic Tumor Growth Hormone Releasing Factor, Peptides, 4:107-11-, 1983.
W. A. Murphy et al., Effects of Secretion and Gastric Inhibitory Polypeptide on Human Pancreatic Growth Hormone-Releasing Factor (1-40)-Stimulated Growth Hormone Levels in the Rat, Biochem. Biophys. Res. Comm, 112:469-474, 1983.
W. Vale et al., Effects of Synthetic Human Pancreatic (Tumor) GH Releasing Factor and Somatostatin, Triodothyronine and Dexamethasone on GH Secretion In Vitro, Endocrinology, 112:1553-1555, 1983.

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