Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-09-26
1997-10-28
Jacobson, Dian C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530399, C07K 1461
Patent
active
056818092
ABSTRACT:
The present invention relates to antagonists of vertebrate growth hormones obtained by mutation of the third alpha helix of such proteins (especially bovine or human GHs). These mutants have growth inhibitory or other GH-antagonizing effects. These novel hormones may be administered exogenously to animals, or transgenic animals may be made that express the antagonist. Animals have been made which exhibited a reduced growth phenotype.
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Chen Wen Y.
Kopchick John J.
Carlson K. Cochrane
Cooper Iver P.
Jacobson Dian C.
Ohio University
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