Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1986-07-31
1988-11-08
Phillips, Delbert K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530324, 530399, C07K 1300
Patent
active
047835249
ABSTRACT:
This invention relates to novel peptides having utility for promotion of growth and/or lactation in animals, to processes and DNA useful in production of such peptides, and to methods utilizing such peptides to promote growth or lactation in animals. In some embodiments, the invention is directed to peptides having bovine IGF-II biological activity, to production of such peptides, and to their use in effecting proliferation of certain cells (e.g. mammary epithelial or muscle) or in enhancing lactation in cattle or other animals.
REFERENCES:
Biological Abstract 79 (12): AB-89, Congote, Similarities in Structure and Function of Bovine Serum ET and Human Insulin-Like Growth Factor II.
Biochem. Genetics 102, 1985, 18643w-Dull et al.-Insulin-Like Growth Factor II Pretursor-Gene Organization in Relation to Insulin Gene Family.
Chemical Abstracts, 94, 1981, 2498h-Owens et al.-Ontogenic Changes in Multiplication-Stimulating Activity.
Hormone Pharmacol. (BA, 77, 1972) 109662h-Partial Purification from Calf Serum of a Fraction w/MSA for Chicken Fibro Blasts.
Hormone Pharmacol. (BA, 92, 1980) Relative Effects of Somatomedins, MSA & Growth Hormone on Myoblasts and Myotubes in Culture, Ewton et al.
Chem. Abstracts, vol. 102, 1985, 179517y.
Chem. Abstracts, vol. 104, 1986, 149403g.
Honegger, A. and Humbel, R. E., Insulin-Like Growth Factors I and II in Fetal and Adult Bovine Serum, 261 (2) J. Biol. Chem. 569-575 (1986).
Humbel, R. E., Insulin-Like Growth Factors, Somatomedins and Multiplication Stimulating Avtivity: Chemistry, XII Hormonal Proteins and Peptides 57-79, edited by Choh Hao Li, Academic Press, Inc., N.Y., N.Y. (1984).
Humbel, R. E., Structure and Function of Insulin-Like Growth Factors, 8 Hormones and Cell Regulation 3-7, edited by J. E. Dumont and J. Nunez. Elsevier Science Publishers B.V. (1984).
Liberti, J. P., Purification of Bovine Somatomedin, 67 (3) Biochem. and Biophys. Res. Comms. 1226-33 (1975).
Kotts Claire E.
Krivi Gwen G.
Larsen Brent R.
McGrath Michael F.
Minnerly John C.
Beck George R.
Beusen Jon H.
Clayman Carol H.
Monsanto Company
Phillips Delbert K.
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