Growth factor receptor binding protein

Details Growth factor receptor binding protein Growth factor receptor binding protein

1997-03-11

1999-02-23

Kemmerer, Elizabeth

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435325, 4353201, 4352523, 435 691, 536 235, 536 243, C12N 1512, C12N 510, C12N 1563

Patent

active

058742247

ABSTRACT:
The present invention provides a human growth factor receptor binding protein (GRBP) and polynucleotides which encode GRBP. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing GRBP and for treating disorders associated with expression of GRBP.

REFERENCES:
D'Alessio, GenBank/EMBL record. Accession No. U14626, Definition: Cloning Vector pSVsport 1 beta lactamese gene. 24 May 1995.
Hillies et al. EST-STS-Two Record. Accession No. RO2185. Definition: ye87g05.1 Homosapiens cDNA clone 124760 3' similar to SP. JT0664. 31 Mar. 1995.
Bowie et al. Science 247, 1306-1310, 1990.
Frantz et al. J. Biol. Chem. 272, 2659-2667, 1997.
Suen, K., et al., "Molecular Cloning of the mouse grb2 gene: Differential interaction of the grb2 adaptor protein with epidermal growth factor and nerve receptors," Molecular and Cellular Biology, vol. 13, No. 9, pp. 5500-5512, XP002064590 Sep. 1993.
Marra, M., et al., "The WashU-HHMI Mouse 3NbMS mus musculus cDNA clone 619186 5'," EMBL Database Entry MMAA75718 , Accession No. AA175718, XP002064591, Feb. 18, 1997.
Lowenstein, E.J. et al., "The SH2 and SH3 Domain-Containing Protein GRB2 Links Receptor Tyrosine Kinases to ras Signaling." Cell (1992) 70:431-442.
Matuoka, K., et al., "Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries." Proc. Natl. Acad. Sci. (1992) 89:9015-9019. (GI 55763).
Egan, S.E., et al., "Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation." Nature (1993) 363:45-51.
Buday, L., et al., "Epidermal Growth Factor Regulates p21.sup.ras through the Formation of a Complex of Receptor, Grb2 Adapter Protein, and Sos Nucleotide Exchange Factor." Cell (1993) 73:611-620.
Clark, S.G., et al., "C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains." Nature (1992) 356:340-344. (GI 134425).

Affiliated with

Also associated with

Rating

Growth factor receptor binding protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Growth factor receptor binding protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Growth factor receptor binding protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-305479