Growth factor receptor antibodies

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303888, 53038885, 5303913, 5303917, 5303873, 536 231, 536 2431, 424 9, 4241781, C07K 1628, C07K 1630

Patent

active

059426020

ABSTRACT:
The present invention is related to single and double chain antibodies to EGF receptor. The invention also relates to toxin conjugates of such antibodies. These antibodies are useful for treating and diagnosing the status of pathological conditions such as cancer and cellular hyper proliferation.

REFERENCES:
Lorimer et al., PNAS 93:14815-14820 (1996).
Wikstrand et al., Cancer Research 55:3140-3148 (1995).
Schmidt et al., Brit. J. Cancer 75:1575-1584 (1997).
Wels et al., International Journal of Cancer, vol. 60, No. 1, pp. 137-144, Jan. 3, 1995.

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