Growth factor-induced proliferation of neural precursor cells in

Details Growth factor-induced proliferation of neural precursor cells in Growth factor-induced proliferation of neural precursor cells in

1995-06-07

1999-11-09

Campbell, Bruce R.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 931, 424 932, 435325, 435360, 435366, 435368, 435377, 435383, 435384, 435440, 435455, 435456, 435457, 514 2, 514 44, A01N 6300, A01N 4304, C12N 500, C12N 508

Patent

active

059808853

ABSTRACT:
A method is described for inducing in vivo proliferation of precursor cells located in mammalian neural tissue by administering to the mammal a fibroblast growth factor and at least one additional growth factor selected from the group consisting of epidermal growth factor, transforming growth factor alpha, and amphiregulin. The method can be used to replace damaged or missing neurons and/or glia. Another method is described for transplanting multipotent neural stem cell progeny into a mammal. The method comprises the steps of administering growth factors to a mammal to induce in vivo proliferation of neural precursor cells, removing the precursor cell progeny from the mammal, culturing the removed cells in vitro in the presence of one or more growth factors that induces multipotent neural stem cell proliferation, and implanting the multipotent neural stem cell progeny into the mammal.

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