Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-03-26
1999-12-21
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 4353201, 435243, 435325, C12N 1518, C12N 1563, C12N 121, C12N 500
Patent
active
060047801
ABSTRACT:
The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
REFERENCES:
patent: 5808007 (1998-09-01), Lee et al.
George et al. Current Methods in Sequence Comparison and Analysis, in Macromolecular Sequencing and Synthesis, pp. 127-149.
McPherron et al., 1993, Journal Biol. Chem. 268:(5): 3444-3449.
Li Haodong
Soppet Daniel R.
Brookes A. Anders
Human Genome Sciences Inc.
Hutzell Paula K.
Saoud Christine
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