Growth factor binding molecules

Details Growth factor binding molecules Growth factor binding molecules

2007-01-02

2007-01-02

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S009100, C514S018700, C514S717000, C514S721000, C530S317000, C530S330000, C568S584000, C568S585000, C568S586000

Reexamination Certificate

active

09811945

ABSTRACT:
Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growth factors and are suitable for treating a subject having tumors or restinosis. In one embodiment a platelet-derived growth factor binding molecule is disclosed that is used to inhibit tumor growth and angiogenesis in solid tumors.

REFERENCES:
patent: 5770380 (1998-06-01), Hamilton et al.
patent: 6262257 (2001-07-01), Gale et al.
International Search Report PCT/US01/08920, dated Aug. 31, 2001.
Blaskovich, M.A. et al., “Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice”; Nature Biotechnology, vol. 18, 2000: 1065-70.
Wilson, I.A. et al., “Structural aspects of antibodies and antibody-antigen complexes”; Ciba Foundation Symp., vol. 159, 1991: 13-39.
Bach, A.C. et al., “Structural studies of a family of high affinity ligands for GPIIb/IIIa”; J. Am. Chem. Soc. vol. 116, 1994; 3207-19.
Park H.D. et al., “Protein surface recognition by synthetic receptors: a route to novel sub-micromolar inhibitors for chymotrypsin”; J. Am. Chem. Soc., vol. 121, 1999: 8-13.
Hamuro, Y. et al., “A calixarene with four peptide loops: an antibody mimic for recognition of protein surfaces”; Agnew. Chemie Int. Ed. Engl., vol. 36, 1997: 2680-83.
Shuker et al., “Solid-phase synthesis of a novel peptide substituted calix[4]arene”; Synlett. No. 2, 2001: 210-13.

Affiliated with

Also associated with

Rating

Growth factor binding molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Growth factor binding molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Growth factor binding molecules will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3785524