Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-06-05
2007-06-05
Qian, Celine (Department: 1636)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C435S320100
Reexamination Certificate
active
10018638
ABSTRACT:
Isolated GDF-9 regulatory sequences are disclosed, as well as methods of using the sequences to modulate tissue-specific expression of genes. The GDF-9 regulatory sequences include, for example, enhancer and promoter elements that naturally drive transcription of GDF-9 in specific tissues. The GDF-9 regulatory sequences can be derived from the untranscribed upstream (e.g., first 10 kilobases) and downstream regions, and transcribed, untranslated regions of a GDF-9 gene.
REFERENCES:
patent: 5614396 (1997-03-01), Bradley et al.
patent: 5821056 (1998-10-01), Lee
patent: WO 95/06118 (1995-03-01), None
patent: WO 97/19180 (1997-05-01), None
patent: WO 97/19180 (1997-05-01), None
EMBL database acc. No. AA388141; vb59g09.r1 Ko mouse embryo 11 5dpcMus musculuscDNA clone IMAGE:761344 5′, mRNA sequence.
EMBL database acc. No. AA035964: mi70f04.r1 Soares mouse embryo NbME13.5 14.5Mus musculuscDNA clone IMAGE:468895 5′ similar to SW:UCR7—BOVIN P13271 Ubiquinol-Cytochrome C Reductase 9.5 KD Protein ;, mRNA sequence.
Bodensteiner, K.J. et al. Molecular cloning of the ovine growth/fifferentiaton factor-9 gene and expression of growth/differentiation factor-9 in ovine and bovine ovaries.Biol. Reprod.Feb. 1999;60(2):381-6.
Carabatsos, M.J. et al. Characterization of oocyte and follicle development in growth differentiation factor-9-deficient mice.Dev. Biol.Dec. 15, 1998;204(2):373-84.
Casadaban, M.J. et al. Analysis of gene control signals by DNA fusion and cloning inEscherichia coli. J. Mol. Biol.Apr. 1980;138(2):179-207.
Dong, J. et al. Growth differentiation factor-9 is required during early ovarian folliculogenesis.Nature.Oct. 10, 1996;383(6600):531-5.
Dube, J.L. et al. The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes.Mol. Endocrinol.Dec. 1998;12(12):1809-17.
Fitzpatrick, S.L. et al. Expression of growth differentiation factor-9 messenger ribonucleic acid in ovarian and nonovarian rodent and human tissues.Endocrinology.May 1998;135(5);2571-8.
Garver, R.I. Jr. et al. Strategy for achieving selective killing of carcinomas.Gene Ther.Jan. 1994;1(1):46-50.
Hayashi, M. et al. Recombinant growth differentiation factor-9 (GDF-9) enhances growth and differentiation of cultured early ovarian follicles.Endocrinology.Mar. 1999;140(3):1236-44.
Incerti, B. et al., Structure of the mouse growth/differentiation factor 9 gene.Biochim. Biophys. Acta.May 26, 1994;1222(1):125-8.
Liang, L.-F. et al. FIGα, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes.Development.Dec. 1997;124(24):4939-47.
Lira, S.A. et al.cis-Acting DNA elements involved in oocyte-specific expression of mouse sperm receptor genemZP3are located close to the gene's transcription start site.Mol. Reprod. Dev.Dec. 1993;36(4):494-9.
McGrath, S.A. et al. Oocyte-specific expression of growth/differentiation factor-9.Mol. Endocrinol.Jan. 1995;9(1):131-6.
McPherron, A.C. et al. GDF-3 and GDF-9: two new members of the transforming growth factor-β superfamily containing a novel pattern of cysteines.J. Biol. Chem.Feb. 15, 1993;268(5):3444-9.
Millar, S.E. et al. Oocyte-specific factors bind a conserved upstream sequence required for mouse zona pellucida promoter activity.Mol. Cell. Biol.Dec. 1991;11(12):6197-204.
Sauer, B. Inducible gene targeting in mice using the Cre/loxsystems.Methods.Apr. 1998;14(4):381-92.
Zinkel, S.S. et al. Indentification of a negatie regulatory element that inhibits c-mostranscription in somatic cells.Mol. Cell. Biol.May 1992;12(5):2029-36.
Fitzpatrick, S.L.,et al.“Expression of growth differentiation factor-9 messenger ribonucleic acid in ovarian and nonovarian rodent and human tissues.”Endocrinology.May 1998; 139(5):2571-8.
Elvin Julia Andrea
Matzuk Martin Matthew
Lahive & Cockfield, LLP.
Mandragouras Esq. Amy E.
Metamorphix, Inc.
Qian Celine
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