Growth differentiation factor-8 transgenic mice

Details Growth differentiation factor-8 transgenic mice Growth differentiation factor-8 transgenic mice

1997-02-05

1999-11-30

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 21, 800 22, 800 25, 435455, 435463, 4353201, 435325, C12N 1509, C12N 1500, C12N 1563, C12N 500

Patent

active

059946180

ABSTRACT:
A transgenic mouse whose genome comprises a disruption of the endogenous growth differentiation factor-8 (GDF-8) gene is disclosed. Also disclosed are methods for making such mice. The transgenic mice exhibit a phenotype of increased muscle tissue.

REFERENCES:
patent: 5585479 (1996-12-01), Hoke et al.
Moreadith et al., J. Mol. Med., vol. 75, pp. 208-216, 1997.
Bradley et al., Biotechnology, vol. 10, pp. 534-539, May 1992.
Seamark, Reproduction, Fertility and Development, vol. 6, pp. 653-657, 1994.
Mullins et al., Journal of Clinical Investigation, vol. 98, pp. S37-S40, 1996
Wall, Theriogenology, vol. 45, pp. 57-68, 1996.
Kappel et al., Current Opinion in Biotechnology, vol. 3, pp. 548-553, 1992.
Strojek & Wagner, Genetic Engineering: Priniciples and Methods, vol. 10, pp. 221-246, 1988.
Ebert et al., Molecular Endocrinology, vol. 2, pp. 277-283, 1988.
Hammer et al., Journal of Animal Science, vol. 63, pp. 269-278, 1986.
Gura, Science, vol. 270, pp. 575-577, Oct. 27, 1995.
Zhu et al., Poultry Science, vol. 74, pp. 1067-1073, Abstract only, Jul. 1995.
Faulkner et al., Journal of Animal Science, vol. 67, pp. 1907-1915, Abstract only, Aug. 1989.
McDowell et al., Australian Journal of Biological Sciences, vol. 40, pp. 295-306, Abstract only, 1987.
Evock et al., Journal of Animal Science, vol. 66, pp. 1928-1941, Abstract only, Aug. 1988.
Flakoll et al., Journal of Animal Science, vol. 69, pp. 1461-1467, Abstract only, Apr. 1991.
Deli et al., Archives of Toxicology, vol. 8, pp. 277-279, Abstract only, 1985.

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