Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds hormone or other secreted growth regulatory factor,...
Reexamination Certificate
2005-02-22
2005-02-22
Spector, Lorraine (Department: 1646)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds hormone or other secreted growth regulatory factor,...
C530S387900, C530S388100, C530S389100, C530S399000
Reexamination Certificate
active
06858208
ABSTRACT:
A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals with antibodies or antisense directed to GDF-8. The animals so treated are characterized by increased muscle tissue.
REFERENCES:
patent: 5616561 (1997-04-01), Barcellos-Hoff
patent: 5827733 (1998-10-01), Lee et al.
patent: 6468535 (2002-10-01), Lee et al.
patent: WO 9108291 (1991-06-01), None
patent: WO 9421681 (1994-09-01), None
patent: 9833887 (1998-08-01), None
patent: 9902667 (1999-01-01), None
patent: 9940181 (1999-08-01), None
patent: 9942573 (1999-08-01), None
Martignoni et al. Molecular Cancer, vol. 2 (36), 2003.*
Mountain et al. Biotechnol. Genet, Eng. Rev. 1992, vol. 10, pp. 1-142 (abstract).*
Wan et al., Adv. Exp. Med. Biol. 1985, vol. 185, pp. 175-191 (abstract).*
Constam. Daniel B. and Robertson, Elizabeth J., “Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases,” J. Cell. Biol., vol. 144, No. 5, Jan. 1999, pp. 139-149.
Gonzalez-Cadavid et al., “Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting”, Proc Natl Acad Sci USA., Dec. 1998, 95(25):14938-14943.
McPherron et al., “Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member”, Nature, May 1997, 387(6628):83-90.
Lee Se-Jin
McPherron Alexandra C.
Andres Janet L.
Gray Cary Ware & Freidenrich LLP
Spector Lorraine
The Johns Hopkins University School of Medicine
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