Growth arrest gene compositions and methods

Details Growth arrest gene compositions and methods Growth arrest gene compositions and methods

1997-06-27

1999-12-07

Kemmerer, Elizabeth

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4353201, 435325, 4352523, 435455, 435471, C12N 121, C12N 510, C12N 1512, C12N 1563

Patent

active

059985992

ABSTRACT:
Disclosed is a novel gene and growth arrest gene product encoded by the gene. Expression of the growth arrest gene B4B results in inhibition of cellular proliferation. The gene and gene product serve as markers of cancerous or pre-cancerous conditions, and as markers of immune states.

REFERENCES:
patent: 5399346 (1995-03-01), Anderson et al.
Ben-Porath, Ittai and Nissim Benvenisty, "Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins," Gene 183:69-75 (1996).
Koenig, Scott, "A lesson from the HIV patient: The immune response is still the bane (or promise) of gene therapy," Nature Medicine 2(2): 165-167 (1996).
Marvin, K.W., et al., "Identification and Characterization of a Novel Squamous Cell-associated Gene Related to PMP22," The Journal of Biological Chemistry 270(48):28910-28916 (1995).
Patel, Pragna I., et al., "The gene for the peripheral myelin protein PMP-22 is a candidate for Charcot-Marie-Tooth disease type 1A," Nature Genetics 1:159-165 (1992).
Riddell, S.R., et al., "T-cell medicated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV infected patients," Nature Medicine 2(2):216-223 (1996).
Ruegg, C.L., et al., "B4B, a Novel Growth-Arrest Gene, Is Expressed by a Subset of Progenitor/Pre-B Lymphocytes Negative for Cytoplasmic .mu.-Chain," The Journal of Immunology 157:72-80 (1996).
Taylor, Verdon, et al., "Epithelial Membrane Protein-1, Peripheral Myelin Protein 22, and Lens Membrane Protein 20 Define a Novel Gene Family," The Journal of Biological Chemistry, 270(48):28824-28833 (1995).

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