Group (VII) transition-metal complexes with multidentate...

Details Group (VII) transition-metal complexes with multidentate... Group (VII) transition-metal complexes with multidentate...

2005-08-09

2005-08-09

Jones, Dameron L. (Department: 1616)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

C424S001110, C424S009360, C534S010000, C534S014000

Reexamination Certificate

active

06926883

ABSTRACT:
The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as imaging agents for diagnostic purposes. In accordance with the present invention, a method of preparing a compound of formula (I): fac-[M(CO)3(OH2)3]+, wherein M is Mn,99mTc,186Re or188Re, involves reacting a metal in permetallate form with carbon monoxide and a reducing agent, wherein a mixture of a basic borate buffer and a reducing agent soluble in water but not substantially decomposed by water is solved in a water containing solvent system containing a solution of the metal in permanganate, pertechnetate or perrhenate form in the presence of carbon monoxide. The compound of formula (I) can be reacted with a ligand Lxto form a compound of formula (II): fac-[M(CO)3(X)2L1]n, wherein M is as defined above Lxis a multidentate ligand, and n is a charge of the ligand Lxincreased with one + charge. The invention also is directed to novel compounds, and kits for carrying out the disclosed methods.

REFERENCES:
patent: 6344178 (2002-02-01), Alberto et al.
patent: 6359119 (2002-03-01), Pipes et al.
patent: 1013642 (2000-06-01), None
patent: WO98-48848 (1998-11-01), None
Alberto et al (1995), Journal of Organometallic Chemistry, 493, pp. 119-127.
Alberto et al (1998), J. Am. Chem. Soc, 120, ppl. 7987-7988.

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