Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2006-10-31
2006-10-31
Graser, Jennifer E. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S185100, C424S190100, C424S193100, C424S203100, C530S350000
Reexamination Certificate
active
07128919
ABSTRACT:
This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids encoding Group B streptococcal Ema polypeptides EmaA, EmaB, EmaC, EmaD and EmaE. The present invention provides isolated polypeptides comprising amino acid sequences of Group B streptococcal polypeptides EmaA, EmaB, EmaC, EmaD and EmaE, including analogs, variants, mutants, derivatives and fragments thereof. Ema homologous polypeptides from additional bacterial species, includingS. pneumoniae, S. pyogenes, E. faecalisandC. diptheriaeare also provided. Antibodies to the Ema polypeptides and immunogenic fragments thereof are also provided. The present invention relates to the identification and prevention of infections by virulent forms of streptococci. This invention provides pharmaceutical compositions, immunogenic compositions, vaccines, and diagnostic and therapeutic methods of use of the isolated polypeptides, antibodies thereto, and nucleic acids. Assays for compounds which modulate the polypeptides of the present invention for use in therapy are also provided.
REFERENCES:
patent: WO 98/38312 (1998-03-01), None
patent: WO 98/50554 (1998-12-01), None
patent: WO 00/12132 (2000-09-01), None
patent: WO 00/06736 (2000-10-01), None
patent: WO 00/06737 (2000-10-01), None
patent: WO 00/62804 (2000-10-01), None
patent: WO 00/78787 (2000-12-01), None
Schenk-Groeninger, R. (Submitted. Jan. 1995. EMBL/GenBank accession No. Q48707).
Geysen (J.Molecul.Recognition, 1(1): 32-42) 1988.
Hopp et al. (Proc.Natl.Acad.Sci.USA.1991. 78: 3824-3828).
Rudinger et al. (Jun. 1976. Peptide Hormones. Biol.Council. pp. 5-7).
Mikayama et al. (Nov.1993. Proc.Natl.Acad.Sci. USA, vol. 90 : 10056-10060).
Baker et al. 1998. New Eng.J.Med. 319: 1180-1185.
Madoff et al. 1996. PNAS USA 93 : 4131-4136.
*cited in Applicant's specification.
Manganelli et al., “Characterization ofemb,a Gene Encoding the Major Adhesin ofStreptococcus defectivus”, Infection and Immunity 1999 67 (1) :50-56.
Ozeri et al., “A two-domain mechanism for group A streptococcal adherence through protein F to the extracellular matrix”, The EMBO Journal 1996 15 (5) :989-998.
Patti J.M., “MSCRAMM-Mediated Adherence of Microorganisms to Host Tissues”, Annu. Rev. Microbiol. 1994 58-585-617 XP-001037269.
Patti et al., “Critical Residues in the Ligand-binding Site of theStaphylococcus aureusCollagen-binding Adhesion (MSCRAMM)”, J. Biol. Chem. 1995 270(20) :12005-12011.
Rich et al., “Ace Is a Collagen-binding MSCRAMM fromEnterococcus faecalis”, J. Biol. Chem. 1999 274 (38) :26939-26945.
Spellerberg et al., “Lmb, a Protein with Similarities to the LraI Adhesin family, Mediates Attachment ofStreptococcus agalactiaeto Human Laminin”, Infection and Immunity 67 (2) :871-878.
NCBI Genbank Accession No. NP—687665 [gi:22536814] Aug. 29, 2002-Jan. 17, 2006 with Revision History.
Maione et al., “Identification of a Universal Group BStreptococcusVaccine by Multiple Genome Screen”, Science 2005 309:148-150 and Supporting Online Material.
Adderson Elisabeth
Bohnsack John
Graser Jennifer E.
Licata & Tyrrell P.C.
St. Jude Children's Research Hospital
University of Utah Research Foundation
LandOfFree
Group B streptococcus polypeptides nucleic acids and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Group B streptococcus polypeptides nucleic acids and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Group B streptococcus polypeptides nucleic acids and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3618069