Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1994-04-21
1999-02-02
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
4241931, 4242371, 4242441, 424450, A61K 38385, A61K 3909, A61K 927
Patent
active
058661352
ABSTRACT:
This invention provides a novel immunogenic composition and vaccine, processes for producing them and methods for immunization against infections and disease caused by group A Streptococci. The compositions include group A streptococcal polysaccharide covalently linked to protein or liposomes to form immunogenic conjugates. The method of immunization for this invention comprises administering to an individual an immunogenic amount of group A polysaccharide. The group A polysaccharide may be administered as a vaccine either on its own, conjugated to proteins or conjugated to liposomes. Additionally, the group A polysaccharides may be associated with an adjuvant. This invention is particularly useful for providing both active and passive immunogenic protection for those populations most at risk of contracting group A Streptococcal infections and disease namely adults, pregnant women and in particular infants and children.
REFERENCES:
patent: 4356170 (1982-10-01), Jennings et al.
patent: 4695624 (1987-09-01), Marburg et al.
patent: 5283185 (1994-02-01), Epand et al.
Pinto et al (1991) Carbohydrate Res. 210:199-219.
Pinto et al (1983) Carbohydrate Res. 124:313-318.
Reimer et al (1992) Carbohydrate Res. 228(2):399-414.
McCarty, M. (1956) J. Exp. Med. 104:629-643.
Dick, Jr. et al (1989) Conjugate Vaccines, Contrib Microbiol. Immunol:10-48-114.
Bruyere et al (1987) Vaccine 5:39-42.
K.B. Reimer, et al., "Immunochemical Characterization of Polyclonal and Monoclonal Streptococus Group A Antibodies by Chemically Defined Glycoconjugates and Synthetic Oligosaccharides", Carbohydrate Research, 232:131-142 (1992).
H.M. Fillit, et al., "Immunogenicity of Liposome-Bound Hyaluronate in Mice", J. Exp. Med. 168:971-982 (1988).
H.M. Fillit, et al., "Induction of Antibodies to Hyaluronic Acid by Immunication of Rabbits with Encapsulated Streptococci", J. Exp. Med. 164:762-776 (1986).
J. Rotta, et al., "Biological Properties of Cell Wall Mucopeptide of Hemolytic Streptococci", Institute of Epidemiology and Microbiology, Prague, Czech; First Institute of Pathology, Charles University, Prague, Czech; pp. 31-47 (1969).
R.A. Zimmerman, et al., "Precipitating Antibody to Group A Streptococcal Polysaccharide in Humans", J. of Immuno., No. 3, 107:832-841 (1971).
W.W. Karakawa, et al., "Detection of Streptococcal Group-Specific Antibodies in Human Sera", J. of Experimental Medicine, No. 2, 122:195-205, (1965).
R.C. Lancefield, "Persistence of Type-Specific Antibodies in Man Following Infection with Group A Streptococci", J. of Experimental Medicine, 110:271-292 (1959).
W.C. Schmidt, et al., "The Determination of Antibody to a Group A Streptococcal Polysaccharide in Human Sera by Hemagglutination", Journal of Exp. Med., No. 4, 121:793-806 (1965).
Blake Milan S.
Michon Francis
Tai Joseph Y.
Zabriskie John B.
Achutamurthy Ponnathapura
North American Vaccine, Inc.
The Rockefeller University
LandOfFree
Group A streptococcal polysaccharide immunogenic compositions an does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Group A streptococcal polysaccharide immunogenic compositions an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Group A streptococcal polysaccharide immunogenic compositions an will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1114673