Ground mixture

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514772, 514789, 514951, 424125, 424489, A61K 4700, A61K 914

Patent

active

047726270

ABSTRACT:
A ground mixture of a poorly soluble crystalline drug and an adsorbent is remarkably improved in the rates of dissolution and adsorption of the drug.

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Abdallah et al., "Influence of Dispersion Method on Particle Size and Dissolution of Griseofulvin-silicon Dioxide Triturations", Drug Development and Industrial Pharmacy,9(5), 795-808, (1983).
McGinity et al., "Increasing Dissolution Rates of Poorly Soluble Drugs by Adsorption to Montmorillonite" Drug Development and Industrial Pharmacy, 6(1), 35-48 (1980).
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Yang et al., "Effects of Amorphous Silicon Dioxides on Drug Dissolution", Journal of Pharmaceutical Sciences, vol. 68, No. 5 (1979).

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