Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-01-31
1999-12-14
Kemmerer, Elizabeth
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435325, 4352523, 4353201, 536 235, C12N 121, C12N 510, C12N 1519, C12N 1563
Patent
active
060016051
ABSTRACT:
Two novel cytokines which are involved in an inflammatory response (inflammatory cytokines) are disclosed. The inflammatory cytokines have been isolated from activated peripheral blood, preferably monocytes adhered to plastic; or peripheral blood leukocytes induced with calcium ionophore and mezerin. The two cytokines are Gro .beta. and .gamma., and their cDNA and amino acid sequences are disclosed. The expression of the genes in various cells is presented. Assay and diagnostic utilities using the cytokines; recombinant materials and procedures; purification procedures; and monoclonal antibodies to the cytokines are also shown.
REFERENCES:
patent: 5154921 (1992-10-01), Sager
patent: 5703206 (1997-12-01), Wolpe
Sporn et al., Oct., 1998, J. Leukocyte Biology 44(4):267 (abstract).
Sporn et al., Oct., 1989, J. Leukocyte Biology 46:329.
Sporn et al.. 1990. J. Immunol. 144:4434-4441.
Haskill et al., 1990, Proc. Natl. Acad. Sci. USA 87:7732-7736.
Anisowicz,A. et al. "Functional Diversity of Gro Gene Expression in Human Fibroblasts & Mammary Epithelial Cells". PNAS 85:9645-9649 (1988).
Trask,D. et al. "The Gro Gene as Growth Factor & Cytokine", J. Cell. Biochem. Suppl. O (14 part B) 1990, p. 5.
Tekamp-Olson,P. et al. "Cloning & Characterization of cDNAs for Murine MIP-2 and its Human Homologues", J.Exp.Med. 172:911-919 (1990).
Suggs, et al., Proc. Natl. Acad. Sci. USA, 78:6613-6617 (1981).
Sager, R. Progress in Leukocyte Biology, vol. 10A, Oppenheim, J.J. (ed.), Wiley-Liss, NY, NY (1990).
Haskill John Stephen
Martin George
Nitecki Danute E.
Ralph Peter
Blackburn Robert P.
Chiron Corporation
Kemmerer Elizabeth
Potter Jane E. R.
The University of North Carolina at Chapel Hill
LandOfFree
Gro genes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gro genes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gro genes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-862179