Gro genes

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435325, 4352523, 4353201, 536 235, C12N 121, C12N 510, C12N 1519, C12N 1563

Patent

active

060016051

ABSTRACT:
Two novel cytokines which are involved in an inflammatory response (inflammatory cytokines) are disclosed. The inflammatory cytokines have been isolated from activated peripheral blood, preferably monocytes adhered to plastic; or peripheral blood leukocytes induced with calcium ionophore and mezerin. The two cytokines are Gro .beta. and .gamma., and their cDNA and amino acid sequences are disclosed. The expression of the genes in various cells is presented. Assay and diagnostic utilities using the cytokines; recombinant materials and procedures; purification procedures; and monoclonal antibodies to the cytokines are also shown.

REFERENCES:
patent: 5154921 (1992-10-01), Sager
patent: 5703206 (1997-12-01), Wolpe
Sporn et al., Oct., 1998, J. Leukocyte Biology 44(4):267 (abstract).
Sporn et al., Oct., 1989, J. Leukocyte Biology 46:329.
Sporn et al.. 1990. J. Immunol. 144:4434-4441.
Haskill et al., 1990, Proc. Natl. Acad. Sci. USA 87:7732-7736.
Anisowicz,A. et al. "Functional Diversity of Gro Gene Expression in Human Fibroblasts & Mammary Epithelial Cells". PNAS 85:9645-9649 (1988).
Trask,D. et al. "The Gro Gene as Growth Factor & Cytokine", J. Cell. Biochem. Suppl. O (14 part B) 1990, p. 5.
Tekamp-Olson,P. et al. "Cloning & Characterization of cDNAs for Murine MIP-2 and its Human Homologues", J.Exp.Med. 172:911-919 (1990).
Suggs, et al., Proc. Natl. Acad. Sci. USA, 78:6613-6617 (1981).
Sager, R. Progress in Leukocyte Biology, vol. 10A, Oppenheim, J.J. (ed.), Wiley-Liss, NY, NY (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Gro genes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gro genes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gro genes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-862179

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.