Griseolic acid compounds and their use as a phosphodiesterase in

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514383, 514398, 5483114, 5483154, A61K 31415, C07D23302, C07D23304, C07D23354

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056166001

ABSTRACT:
A compound of the formula (I) is provided ##STR1## wherein A represents a group of the formula: ##STR2## R.sup.1 and R.sup.2 are independently hydrogen, halogen or a group of the formula --OR.sup.9 ; R.sup.9 is hydrogen, alkyl, alkylsulfonyl, haloalkylsulfonyl, arylsulfonyl or a hydroxy-protecting group; R.sup.3 and R.sup.4 are independently carbamoyl or carboxy; R.sup.5 and R.sup.6 both represent hydrogen or together represent an extra carbon-carbon bond between the carbon atoms to which they are attached; and Z represents hydrogen or unsubstituted or substituted hydroxy; or a pharmaceutically acceptable salt or ester thereof. The compounds are useful as inhibitors of phosphodiesterases.

REFERENCES:
patent: 4035370 (1977-07-01), Lorincz et al.
patent: 4167565 (1979-09-01), Stein et al.
patent: 4460765 (1984-07-01), Naito et al.
patent: 4634706 (1987-01-01), Kaneko et al.
patent: 4783532 (1988-11-01), Kaneko et al.
patent: 4788190 (1988-11-01), Saksena et al.
patent: 4803271 (1989-02-01), Verheyden et al.
patent: 4822879 (1989-04-01), Nakagawa et al.
patent: 4966912 (1990-10-01), Ralyea et al.
patent: 5091431 (1992-02-01), Tulshian et al.
N. D. Goldberg et al, "Biologic Regulation Through Opposing Influences of Cyclic GMP and Cyclic AMP: The Yin Yang Hypothesis", pp. 307-330, 1975, Advances in Cyclic Nucleotide Research, vol. 5.
Joseph Segal, "Opposite Regulatory Effects of cAMP and cGMP on Sugar Uptake in Rat Thymocytes", 1987, pp. E588-E594, Am, J. Physiol., 252.
Daiichi Seiyaku, "Bucladesine Sodium", vol. 10, No. 2, 1985 Drugs of the Future.
M. Hagiwara et al, "Effects of Vinpocetine on Cyclic Nucleotide Metabolism in Vascular Smooth Muscle", vol. 33, No. 3, pp. 453-457, 1984, pp. 453-457, Biochemical Pharmacology.
Tohru Ueda, Kazunobu Miuyra and Tsuguo Kasai, "Synthesis of 6-Thioguanine and 2,6-Diaminopurine Nucleosides and Nucleotides from Adenine Counterparts via a Facile Rearrangement in the Base Portion (Nucleosides and Nucleotides. XIX)".
Chem. Pharm. Bull., 26, 2122-2127 (1978).
Chemical Abstracts, vol. 106, No. 7, 1987, pp. 683-684, Abstract No. 50602a of JP 61-100593 which was published May 1986.

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