Griseofulvin dosage forms

Details Griseofulvin dosage forms Griseofulvin dosage forms

1975-06-25

1976-08-03

Rosen, Sam

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424285, A61K 3174, A61K 3134

Patent

active

039729990

ABSTRACT:
Completely miscible melt mixes of amorphous griseofulvin and certain polyglycolides or lactic acid modified polyglycolides are described which are formed by melting together griseofulvin and the polyglycolide or lactic acid modified polyglycolide, the latter having a molecular weight less than 2000 and a glycolic acid content of about 60 to 100 mole per cent. The cooled melt is transparent, glassy and capable of being finely divided. The griseofulvin contained therein, between 30 and 60% by weight, is amorphous and the finely divided melt mixture can be subdivided and incorporated into dosage forms.

REFERENCES:
florestano - Chem. Abst., vol. 70 (1969), p. 118078e.
Chem. Abst., 8th Coll. Index, vol. 66-75, (1967-1971), p. 14091s.

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