GRB2 associating polypeptides and nucleic acids encoding therefo

Details GRB2 associating polypeptides and nucleic acids encoding therefo GRB2 associating polypeptides and nucleic acids encoding therefo

1995-11-17

1999-12-14

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Transferases

435 21, 435 691, 435194, 4352523, 4353201, 530300, 530350, 536 232, A61K 3851, C12Q 142, C12N 912, C07K 100

Patent

active

060013540

ABSTRACT:
The present invention generally relates to novel GRB2 associating proteins and nucleic acids which encode these protein. In particular, these novel proteins possess inositol polyphosphate 5-phosphatase and phosphatidylinositol 5-phosphatase activities, important in growth factor mediated signal transduction. As such, the proteins, nucleic acids encoding the proteins, cells capable of expressing these nucleic acids and antibodies specific for these proteins will find a variety of uses in a variety of screening, therapeutic and other applications.

REFERENCES:
Motto et al. (1994). J. Biol. Chem. 269 (34):21608-613, Aug. 26, 1994.
Berridge and Irvine, "Inositol phosphates and cell signalling," Nature, 341:197-205 (1989).
Cantley et al., "Oncogenes and Signal Transduction," Cell, 74:1657 (1993).
Clark et al., "C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains," Nature, 356:340-344 (1992).
Fantl et al., "Distinct Phosphotyrosines on a Growth Factor Receptor Bind to Specific Molecules that Mediate Different Signalling Pathways," Cell, 69:413 (1992).
Hawkins et al., "Platelet-derived growth factor stimulates synthesis of PtdIns (3,4,5)P.sub.3 by activating a PtdIns (4,5) P.sub.2 3-OH kinase," Nature, 358:157-159 (1992).
Hu et al., "Binding of NCK to SOS and Activation of ras-Dependent Gene Expression," Mol. Cell. Biol., 15:1169-1174 (1995).
Janknecht et al., "Signal Integration at the c-fos Promoter, " Carcinogenesis, 16(3):443-450 (1995).
Katzav et al., "vav, a Novel Human Oncogene Derived from a Locus Ubiquitously Expressed in Hematopoietic Cells, " EMBO J., 8:2283-2290 (1989).
Klippel et al., "The C-Terminal SH2 Domain of p85 Accounts for the High Affinity and Specificity of the Binding of Phosphatidylinositol 3-Kinase to Phosphorylated Platelet-Derived Growth Factor .beta. Receptor," Mol. Cell. Biol. 12(4):1451-1459 (1992).
Maruta and Burgess, "Regulation of the Ras signalling Network," Bioessays, 16(7):489-496 (1994).
Piechaczyk et al., "c-fos Proto-Oncogene Regulation and Function," Crit. Rev. Oncol./Hematol., 17(2):93-131(1994).
Pot et al., "Cloning and Characterization of a Novel Grb2 Associateing Protein Binding Through the SH3 Domains of Grb2; Similarity to Inositol Polyphosphate 5' Phosphatase," Conference on Signal Transduction of Normal and Tumor Cells, Banff, Alberta, Canada, Apr. 1-6, 1995.
Stephens et al., "Pathway of phosphatidylinositol(3,4,5)-triphosphate synthesis in activated neutrophils," Nature, 351:33-39 (1991).
Stern et al., "The Human GRB2 and Drosophila Drk Genes Can Functionally Replace the Caenorhabditis elegads Cell Signalling Gene sem-5," Mol. Biol. Cell, 4:1175-1188 (1993).
Valius et al., "Phospholipase C-.gamma.l and Phosphatidylinositol 3 Kinase are the Downstream Mediators of the PDGF Receptor's Mitogenic Signal," Cell, 73:321 (1993).
York et al., "Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase," PNAS, 87:9548-9552 (1990).
Damen, J.E., et al., "The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase," Proc. Natl. Acad. Sci., 93:1689-1693 (1996).
Hejna, J.A., et al., "Cloning and Characterization of a Human cDNA (INPPLI) Sharing Homology with Inositol Polyphosphate Phosphatases," Genomics, 29:285-287 (1995).
Jackson, S.P., et al., "Phosphatidylinositol 3,4,5-triphosphate is a substrate for the 75 kDA inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/p110 form of phosphonositide 3-kinase," The EMBO Journal, 14(18):4490-4500 (1995).
Kavanaugh, W.M., et al., "Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2," (Research Paper) Current Biology, 6(4):438-445 (1996).
Laxminarayan, K.M., et al., "Characterization of cDNA Encoding the 43-kDA Membrane-associated Inositol-polyphosphate 5-Phosphatase," J. Biol. Chem., 269(25):17305-17310, Issue of Jun. 24 (1994).
Norris, F.A., et al., "The Isolation and Characterization of cDNA Encoding Human and Rat Brain Inositol Polyphosphate 4-Phosphatase," J. Biol. Chem, 270(27):16128-16133, Issue of Jul. 7 (1995).
Odai, H. "The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutivity Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells," J. Biol. Chem., 270(18):10800-10805, Issue of May 5 (1995).

Affiliated with

Also associated with

Rating

GRB2 associating polypeptides and nucleic acids encoding therefo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with GRB2 associating polypeptides and nucleic acids encoding therefo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and GRB2 associating polypeptides and nucleic acids encoding therefo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-860459