Graphite impregnated prosthetic vascular graft materials

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Arterial prosthesis – Stent structure

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623 66, A61F 206

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059192232

ABSTRACT:
The specification teaches thromboresistant compositions made of suitable biologically compatible plastic materials and a substance having a negative charge, e.g., graphite, incorporated therein in the framework of the lattices of the plastic, for use in prosthetic vascular devices intended to be permanently grafted in body loci wherein use of a thromboresistant prosthetic is desirable. An exemplary combination is polytetrafluoroethylene and graphite made into suitable structures for use as prosthetic arteries, veins and heart valves is taught.

REFERENCES:
Studies on the Porous Polytetrafluoroethylene as The Vascular Prosthesis: Matsumoto, et al., Artificial Organs, vol. 1, No. 1, 1972, pp. 44-47.
Experimental Studies on the Expanded Polytetrafluoroethylene as The Vascular Prosthesis--The Second Report: It is Applicability to Vein, Matsumoto, et al., Artificial Organs, Supplement 1973, pp. 15-17.
Studies on Expanded Polytetrafluoroethylene as the Vascular Prosthesis (The Third Report): Its Antithrombogencity, Surface Properties and Porosity, Matsumoto, et al., Artificial Organs, vol. 3, No. 5, 1974, pp. 337-341.
Studies on Expanded Polytetrafluoroethylene as the Vascular Prosthesis (The Third Report): Its Antithrombogenecity, Surface Properties and Porosity, Matsumoto, et al., Artificial Organs, vol. 2, Supplement 1973.
Application of Expanded Polytetrafluoroethylene to Vascular Prosthesis (The 4th Report: Comparison between Expanded Polytetrafluoroethylene and Polytetrafluoroethylene-methylmetacrylate Graftcopolymer Implanted into the Portal Vein, Matsumoto, et al. Artificial Organs, vol. 3 Supplement published Sep. 30, 1974.
Application of Expanded Polytetrafluoroethylene to Vascular Prosthesis--Application to the Portal Vein System, and Pore and Pseudo-intima, Kimura, Matsumoto, et al., Artificial Organs, vol. 5, No. 2, 1976, pp. 85-89.
Experimental Studies of Gore-Tex Graft for Replacement of the Vena Cave--Effect of Anticoagulants, Fujiwara, et al., Artificial Organs, vol. 5, No. 2, 1976, pp. 105-111.
A New Venous Prosthesis, Soyer, Lempinen, Cooper, et al., Surgery, vol. 72, No. 6, 1972, pp. 864-872.
Replacement of Portal Vein During Pancreatectomy for Carcinoma, Norton and Eiseman, Surgery, vol. 77, No. 2, pp. 280-284, Feb. 1975.
Junkosha Japanese Patent Publication No. 22792/74 filed Jun. 22, 1972, published Feb. 28, 1974.
A-V Shunts Created in New Ways, Volder, et al., Trans ASAIO, vol. XIX, pp. 38-42, 1973.
Induced Growth of Connective Tissue in Cardiovascular Prosthesis Volder, et al., Trans ASAIO, vol. XX, pp. 521-529, 1974.
Use of Goretex Grafts For Replacement of the Superior and Inferior Venae Cavae, Fujiwara, et al., The Journal of Thoracic and Cardiovascular Surgery, vol. 67, No. 5, pp. 774-779, May '74.
Expanded Polytetrafluoroethylene (PTFE)--A Superior Biocompatible Material for Vascular Prostheses, Goldfarb, et al., Proc. San Diego Biomed. Symp. 14:451 (Jan./Feb. 1975).
A Small Arterial Substitute: Expanded Microporous Polytetrafluoroethylene: Patency Versus Porosity, Campbell, et al., Annals of Surgery, vol. 182, No. 2, pp. 138-143, submitted for publication Mar. 24, 1975.
Small Vessel Replacement With Gore-Tex (Expanded Polytetrafluoroethylene), Florian, et al., Arch Surg, vol. 111, pp. 267-270, Mar. 1976.
Graphite-Expanded Polytetrafluorethylene: An Improved Small Artery Prosthesis, Goldfarb, et al., vol. XXIII, Trans.Am.Soc. Artif.Intern.Organs, 1977, pp. 268-276.
Campbell et al. "Expanded Polytetrafluoro-ethylene as a Small Artery Substitute" vol. XX Trans. Amer. Soc. Artif. Int. Organs, 1974. pp. 86-90.
Gott et al. "The coating of intravascular plastic prostheses with colloidal graphite", Surgery, vol. 50, No. 2, Aug. 1961, 623-2.
"A new vascular prosthesis for small caliber artery" by H. Matsumoto et al, Surgery, vol. 74, No. 4, pp. 519-523 3-1.4 Oct. 1973.

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