Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-12-14
2008-12-02
Gupta, Anish (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07459439
ABSTRACT:
Granulysin peptides are small antimicrobial agents with potent activity against bacteria and inflammation. A pharmaceutical composition comprising granulysin peptides as an active agent is administered therapeutically to a patient suffering from a microbial infection.
REFERENCES:
patent: 4994369 (1991-02-01), Krensky
patent: 6485928 (2002-11-01), Stenger et al.
patent: 2002/0044927 (2002-04-01), Stenger et al.
Simpson, “Antibiotics in acne: time for a rethink,” British Journal of Dermatology (2001): 144: 225-228.
Anderson et al., Granulysin crystal structure and a structure-derived lytic mechanism, (2003), J Mol Biol., 325(2):355-65.
Bender et al.,Pseudomonas syringaePhytotoxins: Mode of Action, Regulation, and Biosynthesis by Peptide and Polyketide Synthetases, (1999), Microbiology and Molecular Biology Reviews, Jun. 1999, 63(2): 266-292.
Donlon et al., Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome 2p12—q11, (1990), Cytogenet. Cell Genet., 53:230-231.
Ernst et al., Granulysin, a T Cell Product, Kills Bacteria by Altering Membrane Permeability, (2000), J. Immunol., 165:7102-7108.
Jongstra et al., The isolation and sequence of a novel gene from a human functional T cell line (1987), J. Exp. Med., 165:601-614.
Jones et al., Antimicrobial Activity and Spectrum of LY146032, a Lipopeptide Antibiotic, Including Susceptibility Testing Recommendations, (1987), Antimicrob Agents Chemother., 31(4):625-9.
Kandimalla et al., Effect of fatty acids on the permeation of melatonin across rat and pig skin in-vitro and on the transepidermal water loss in rats in-vivo, (1999), J Pharm Pharmacol., 51(7):783-90.
Kumar et al., Granulysin: a novel antimicrobial, (2001), Expert Opin Investig Drugs, 10(2):321-9.
Manning et al., Genomic structure and alternative splicing of 519, a gene expressed late after T cell activation, (1992), J. Immunol., 148:4036-4042.
Ofek et al., Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice, (1994), Antimicrobial Agents and Chemotherapy, 38(2): 374-377.
Setoh et al., Improvement of transdermal delivery of tetragastrin by lipophilic modification with fatty acids, (1995), J Pharm Pharmacol., 47(10):808-11.
Stenger et al., An antimicrobial activity of cytolytic T cells mediated by granulysin, (1998) Science 282(5386):121-5.
Veuillez et al., Synthesis and characterization of an acylated di-peptide (Myr-Trp-Leu) with modified transmucosal transport properties, (1999), Eur J Pharm Biopharm., 48(1):21-6.
Wakabayashi et al., N-Acylated and D enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity, (1999), Antimicrobial Agents and Chemotherapy, 43(5): 1267-1269.
Wan et al., Improving pharmacokinetic properties of adrenocorticotropin by site-specific lipid modification, (2003), J Pharm Sci., 92(9):1882-92.
Wang et al., Bactericidal and Tumoricidal Activities of Synthetic Peptides Derived from Granulysin, (2000), J Immunol., 165(3):1486-90.
Yamamoto et al., Enhanced transdermal delivery of phenylalanyl-glycine by chemical modification with various fatty acids, (2003), Int J Pharm., 250(1):119-28.
Anderson Daniel H.
Eisenberg David S.
Gallo Richard L.
Kim Jenny J.
Modlin Robert L.
Bozicevic Field & Francis LLP
Gupta Anish
Heard Thomas S
Sherwood Pamela J.
The Regents of the University of California
LandOfFree
Granulysin peptides and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Granulysin peptides and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Granulysin peptides and methods of use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4020396