Granulysin peptides and methods of use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07459439

ABSTRACT:
Granulysin peptides are small antimicrobial agents with potent activity against bacteria and inflammation. A pharmaceutical composition comprising granulysin peptides as an active agent is administered therapeutically to a patient suffering from a microbial infection.

REFERENCES:
patent: 4994369 (1991-02-01), Krensky
patent: 6485928 (2002-11-01), Stenger et al.
patent: 2002/0044927 (2002-04-01), Stenger et al.
Simpson, “Antibiotics in acne: time for a rethink,” British Journal of Dermatology (2001): 144: 225-228.
Anderson et al., Granulysin crystal structure and a structure-derived lytic mechanism, (2003), J Mol Biol., 325(2):355-65.
Bender et al.,Pseudomonas syringaePhytotoxins: Mode of Action, Regulation, and Biosynthesis by Peptide and Polyketide Synthetases, (1999), Microbiology and Molecular Biology Reviews, Jun. 1999, 63(2): 266-292.
Donlon et al., Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome 2p12—q11, (1990), Cytogenet. Cell Genet., 53:230-231.
Ernst et al., Granulysin, a T Cell Product, Kills Bacteria by Altering Membrane Permeability, (2000), J. Immunol., 165:7102-7108.
Jongstra et al., The isolation and sequence of a novel gene from a human functional T cell line (1987), J. Exp. Med., 165:601-614.
Jones et al., Antimicrobial Activity and Spectrum of LY146032, a Lipopeptide Antibiotic, Including Susceptibility Testing Recommendations, (1987), Antimicrob Agents Chemother., 31(4):625-9.
Kandimalla et al., Effect of fatty acids on the permeation of melatonin across rat and pig skin in-vitro and on the transepidermal water loss in rats in-vivo, (1999), J Pharm Pharmacol., 51(7):783-90.
Kumar et al., Granulysin: a novel antimicrobial, (2001), Expert Opin Investig Drugs, 10(2):321-9.
Manning et al., Genomic structure and alternative splicing of 519, a gene expressed late after T cell activation, (1992), J. Immunol., 148:4036-4042.
Ofek et al., Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice, (1994), Antimicrobial Agents and Chemotherapy, 38(2): 374-377.
Setoh et al., Improvement of transdermal delivery of tetragastrin by lipophilic modification with fatty acids, (1995), J Pharm Pharmacol., 47(10):808-11.
Stenger et al., An antimicrobial activity of cytolytic T cells mediated by granulysin, (1998) Science 282(5386):121-5.
Veuillez et al., Synthesis and characterization of an acylated di-peptide (Myr-Trp-Leu) with modified transmucosal transport properties, (1999), Eur J Pharm Biopharm., 48(1):21-6.
Wakabayashi et al., N-Acylated and D enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity, (1999), Antimicrobial Agents and Chemotherapy, 43(5): 1267-1269.
Wan et al., Improving pharmacokinetic properties of adrenocorticotropin by site-specific lipid modification, (2003), J Pharm Sci., 92(9):1882-92.
Wang et al., Bactericidal and Tumoricidal Activities of Synthetic Peptides Derived from Granulysin, (2000), J Immunol., 165(3):1486-90.
Yamamoto et al., Enhanced transdermal delivery of phenylalanyl-glycine by chemical modification with various fatty acids, (2003), Int J Pharm., 250(1):119-28.

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